Diabetic Neuropathy Detection

Due to the unfavorable prognosis of advanced stages of diabetic neuropathy (DN), the ideal approach is to identify renal involvement as early as possible. It is recommended to measure urinary albumin excretion (UAE) annually, in random urine samples, in order to detect the stages of DN [microalbuminuria (UAE 17-174 mg/l or 30-300 mg albumin/g of creatinine) and macroalbuminuria (> 174 mg/l or > 300 mg/g)]. Finally, new strategies that could detect DN even earlier, include bio markers such as proteomics, defining a profile of urinary protein excretion able to identify the subsequent risk of renal disease.